I agree Dr. Bredesen's protocol probably can't hurt as it advocates a healthy lifestyle and diet, but there is NO evidence that it can prevent or reverse Alzheimers[1], as he claims. Also, Dr. Bredesen charges $1800+ for the protocol[2] in addition to selling branded supplements.
There is evidence, but I agree it is not rigorous and does not rise to the level of proof. I hope it can inspire other researchers to research parts of it more thoroughly.
With respect to Dayan Goodenowe and his Plasmalogen theory, I think the Rush study should be reproduced by other groups. I am no qualified to judge it either, but thinking critically, unless some glaring statistical mistakes were made, or error measuring the levels, or simply that plasmalogen deficiency is a biomarker more than causative (he goes at length as to why he considers it to be the latter), we are talking about natural compounds (Plasmalogen precursors, or IV plasmalogens) that do not require FDA approval, so it should be fairly straightforward to fund, develop and test.
“The clinical implications of this study are obvious. This is the first reported evidence of a metabolic phenotype with the same clinical characteristics as the APOE ε2ε3 genotype. The probability of dementia in participants with either a high PBV or an APOE ε2ε3 genotype was indistinguishable”
>In fact, we now have compelling epidemiological evidence that vaping almost doubles risk of cardiac events [1].
Somewhat misleading since more than half of those studied were smoking and vaping. From the study:
Among the 9,352 current and former e-cigarette users, 333 (3.6 percent) had experienced a heart attack at some point, with the highest percentage (6.1 percent) among those who used e-cigarettes daily. In the analysis, a quarter of the 2,259 people who currently used e-cigarettes were former smokers of conventional cigarettes and about 66 percent of current e-cigarette users were also current cigarette smokers.
Even that article says that, though catching up on the weekend is better than not trying to catch up at all, consistency (i.e. not falling behind in the first place) is best.
When apoptosis fails, it's might be because p53 binds to foxo4 and gets stuck in the nucleus which prevents the p53 from getting to the mitochondria. In the experiment p53 in the paper, p53 unbound from foxo4 in the nuclease and bound to foxo4-dri and successfully flowed down the mitochondria so apoptosis could occur.
It is really sad that instead of discussing the merit of his argument, we are debating the quality of OP's site.
It is ridiculous that I have to police my site for low quality inbound links or risk getting banned (even more so for mom and pop webmasters who are more susceptible to link penalties). Lastly, if you are penalized, try recovering unless you are big brand like Overstock or JCPenney with millions per year in Adwords spend.
