Also keep in mind that depression isn't always caused by serotonin issues or remediated by increasing serotonin (which is somewhat redundant with this article, though I think the article paints serotonin too negatively).
For example, if someone has bipolar disorder (or similar issues), they may have fairly standard serotonin concentration and receptor activation, but an SSRI may not help much with their depression.
True, but the thought is that the feelings of worthlessness, hopelessness, even suicide are seratonin related. There are other types of depression like "don't enjoy things I used to like, lack mental acuity" that may be dopamine related. And "mopey, lack energy" which may be noradrenaline related.
>True, but the thought is that the feelings of worthlessness, hopelessness, even suicide are seratonin related.
Not necessarily true. People on SSRIs can still want to commit suicide after serotonin rebounds and is at a stable level.
I think complex feelings like despair and self-hatred can't be explained by just a single neurotransmitter. Serotonin likely plays a role here, but it's not the only component.
For example, if someone has bipolar disorder (or similar issues), they may have fairly standard serotonin concentration and receptor activation, but an SSRI may not help much with their depression.