> the connectome is there, we know all the neurons and their connections
No- each synapse has its particular neurotransmitters, and the distance, size, shape, number of receptors, and associated glial cells have very large impacts on transmission. The distance and thickness of axons also impacts the strength of signal delivered. That's all very hard to measure.
Neurons are also very sensitive to signal strength and timing. Eg inhibitory synapses work by opening holes in the cell wall, causing them to leak charge over time. You get that rate slightly wrong and it can hugely change the behavior of the cell.
The connectome is a bit like an untrained model of insane complexity, and each neuron has several weights that describe behavior over time as well as in direct response to signals. Without the weights it can't be emulated.
No- each synapse has its particular neurotransmitters, and the distance, size, shape, number of receptors, and associated glial cells have very large impacts on transmission. The distance and thickness of axons also impacts the strength of signal delivered. That's all very hard to measure.
Neurons are also very sensitive to signal strength and timing. Eg inhibitory synapses work by opening holes in the cell wall, causing them to leak charge over time. You get that rate slightly wrong and it can hugely change the behavior of the cell.
The connectome is a bit like an untrained model of insane complexity, and each neuron has several weights that describe behavior over time as well as in direct response to signals. Without the weights it can't be emulated.