Doesn't many of those extensions due the exact same thing? Like why have Ghostery, DDG Privacy Essentials, Privacy Badger and to some extend uBlock Origin and Decentraleyes (maybe uMatrix as well), either one would do.
heads up, I think Decentraleyes has been superseded by a "LocalCDN", it's more frequently updated and I thing Decentraleyes has bee abandoned by the devs.
I have to temp-trust some elements in NoScript, then look in uMatris for the specific items I'll set to green. That probably sounds like a hassle and I get that. But I've been doing it for so long it's the norm.
If I need to unblock trackers in NS, I close the tab and go on my way.
And every once in a while I'll factory reset both NS and uM.
This probably sounds very tinfoil territory but as I've said I'm happy with my internet experience.