For whatever it's worth, I often use my work PC via the default Windows 10 Remote Desktop client on my laptop (old 15" Macbook Pro, running Windows via Boot Camp): 1 x 2880x1800 hi-DPI display, 2 x normal-DPI 1440x2560 portrait displays. Remote Desktop seems to have no problem using every pixel.
A lot of stuff does get confused by the mixed-DPI setup, but it's not obviously different from running the same programs locally.
A lot of stuff does get confused by the mixed-DPI setup, but it's not obviously different from running the same programs locally.