Yup! We're big fans of IPython. So much so that we collaborated with them on two front2: IPython on Azure (w a Linux or Windows backend): https://www.windowsazure.com/en-us/develop/python/tutorials/... and directly incorporating its REPL into PTVS (right window): http://i.imgur.com/tyvjN.png

With the IPython notebook on Azure you can basically use Linux/Mac with Chrome, FF, Safari, ... and have a nice browser based Python IDE and completely cut Windows & IE out of the picture :).