Hm, I don't think so. For example, if someone strongly believe in freedom of speech, I can't see how that would be an easy target for the kind of mockery seen in today's pranks.
The whole idea of (today's) "lulz" is to make people who are defensive about something react in a completely over the top manner. Rational people are rarely defensive and don't tend to overreact, so they are rarely targeted, and it would be a failure if they were. Hence, if you have a belief that tends to make you overreact defensively when teased about it, it is probably flawed. That was my point.
The only way to not be a target is to believe in "nothing". He who stands for nothing will fall for anything. That's not a good way to live.