I've had "Click to Flash" turned on in Chrome for a while - I found running flash by default was having a measurable impact on my battery life. Turning it off makes Chrome more responsive and nets me an (anecdotal) increase in longevity when I'm away from the charger.
Flashblock on Firefox does the same thing, and I run with it rather than AdBlocker. Blocking flash removes the most painful advertising, leaving more appropriate, less in-your-face advertising as a sort of compromise for the vendors. The 'net is noticably louder when I go onto a machine without flash being blocked.